继续医学教育Issue(11)：14-16,3.DOI:10.3969/J.ISSN.1004-6763.2013.11.007
不同给药时间对非杓型老年高血压患者血压昼夜节律及清晨血压的影响
Effect of different drug administration time on blood pressure circadian rhythm and morning blood pressure of non dipper type dosing in elderly hypertensive
于淼 1李潞 1熊亦涵2
作者信息
- 1. 沈阳医学院附属第二医院心内科，辽宁 沈阳 110002
- 2. 沈阳市志成中学
- 折叠
摘要
Abstract
Objective To investigate effect of different drug administration time on blood pressure circadian rhythm and morning blood pressure of non dipper type dosing in elderly hypertensive. Methods 98 elderly non dipper hypertensive patients were selected , randomly divided into two groups, and were given amlodipine besylate 5mg for 12 weeks in the early morning and evening. Before and after treatment, two groups had monitored ambulatory blood pressure, recorded the mean blood pressure changes in day and night, calculated the percentage of circadian blood pressure difference, measured the early morning blood pressure with family self testing during, and calculated the morning blood pressure mean value and standard rate. Results After 12 weeks, the blood pressure circadian difference giving drug at night were higher than in the morning (P<0.05). No matter the family self testing early morning blood pressure in SBP or DBP, evening medication group were lower than control group in the morning, and the success rate was better (P<0.05). Conclusion Evening medication group adjusts better non dipper circadian rhythm of blood pressure in patients with essential hypertension in elderly patients and reduces the morning blood pressure.关键词
非杓型高血压/清晨血压/动态血压监测Key words
Non dipper type hypertension/Early morning blood pressure/Ambulatory blood pressure monitoring分类
医药卫生引用本文复制引用
于淼,李潞,熊亦涵..不同给药时间对非杓型老年高血压患者血压昼夜节律及清晨血压的影响[J].继续医学教育,2013,(11):14-16,3.
