解放军医学院学报Issue(10)：1003-1006,4.DOI:10.3969/j.issn.2095-5227.2013.10.001
老年弥漫大B细胞淋巴瘤的临床病理学特征及疗效分析-附15例报告
Clinicopathological features of elderly patients with diffuse large B-cell lymphoma and its therapeutic effect:A report of 15 cases
摘要
Abstract
Objective To study the clinicopathological features of elderly patients with diffuse large B-cell lymphoma (DLBCL) and its therapeutic effect. Methods Fifteen elderly DLBCL patients with a mean age of 84 years admitted to our hospital from January 2003 to December 2012 were included in this study. Their clinical data including general clinical characteristics, pathological features, chemotherapy and its effect were retrospectively analyzed. Results Of the 15 DLBCL patients who suffered from at least 2 underlying diseases with hypertension and coronary arteriosclerotic heart disease being most predominant, 4 were complicated by a secondary tumor, 13 had B symptoms (such as fever, night sweat and loss of body weight), 10 were diagnosed as non-GCB type, 1 was classified as Ann-ArborⅡand 14 were classified as Ann-ArborⅢ/Ⅳ, 1 had an IPI score≤2 and 14 had an IPI score of 3-5. The serum LDH level was elevated in 10 patients at their first visit. The patients underwent R-CHOP-based individual chemotherapy with complete remission, partial remission, stable disease, and progressive disease achieved in 4, 8, 1 and 2 patients, respectively, after 4 cycles of chemotherapy. Twelve patients responded to chemotherapy. The overall survival (OS) time was 6 months in 10 patients and 1 year in 8 patients. The progression-free survival (PFS) time was 6 months in 7 patients and 1 year in 6 patients. Conclusion DLBCL in elderly patients is usually complicated by other pre-existing diseases and diagnosed at its late stage, with non-GCB as its pain pathological subtype and a poor prognosis. Elderly DLBCL patients should receive R-CHOP-based individual chemotherapy on the basis of intensified supportive treatment.关键词
弥漫大B细胞淋巴瘤/病理学/老年人Key words
diffuse large B-cell lymphoma/pathology/aged分类
医药卫生引用本文复制引用
蔡力力,卢学春,朱宏丽,冉海红,汪宣池,杨波,李素霞,杨洋,翟冰,于睿莉..老年弥漫大B细胞淋巴瘤的临床病理学特征及疗效分析-附15例报告[J].解放军医学院学报,2013,(10):1003-1006,4.基金项目
国家自然科学基金项目(81273597；30873086；81172986)；中央保健研究基金(B2009B115)；科技部新药创制重大专项(2008ZXJ09001-019)；解放军总医院科技创新苗圃基金(11KMM24；13KMM18)@@@@ Supported by the National Natural Science Foundation of China (81273597 （81273597；30873086；81172986）
30873086 （）
81172986) （）
Chinese Central Health Committee Foundation (B2009B115) （B2009B115）
National Science and Technology Major Projects for"Major New Drugs Innovation and development"(2008ZXJ09001-019) （2008ZXJ09001-019）
