解放军医学院学报Issue(10)：1059-1062,4.DOI:10.3969/j.issn.2095-5227.2013.10.019
骨髓基质细胞移植对大鼠脊髓损伤后环氧化酶-2和血管内皮生长因子表达的影响
Effect of bone marrow stromal cells transplantation on expressions of cyclooxygenase-2 and vascular endothelial growth factor in rats following spinal cord injury
摘要
Abstract
Objective To observe the effect of bone marrow stromal cells (BMSCs) transplantation on expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) protein in rats following spinal cord injury (SCI). Methods Adult rats were randomly divided into group A (sham operation group), group B (DMEM control group), and group C (BMSCs transplantation group). A rat spinal cord compression injury model was established. Rats in groups B and C were injected with BMSCs or DMEM after SCI. Expression of COX-2 and VEGF protein in rats following SCI was detected by Western blot. Results The expression level of COX-2 and VEGF protein was low in group A. The expression level of COX-2 and VEGF protein was significantly higher in group B than in group A and in group C than in group B (P<0.01, P<0.05). Conclusion BMSCs transplantation can up-regulate the expression of COX-2 and VEGF protein in rats following SCI.关键词
脊髓损伤/骨髓基质细胞/环氧化酶-2/血管内皮生长因子/细胞移植Key words
spinal cord injury/bone marrow stromal cells/cyclooxygenase-2/vascular endothelial growth factor/cell transplantation分类
医药卫生引用本文复制引用
于德水,曹阳,梅晰凡,王岩松,闫鹏,吕刚..骨髓基质细胞移植对大鼠脊髓损伤后环氧化酶-2和血管内皮生长因子表达的影响[J].解放军医学院学报,2013,(10):1059-1062,4.基金项目
辽宁省博士科研启动基金项目(20121096)；辽宁医学院博士及出国进修一年以上教师科研启动基金项目(Y2012B011)@@@@Supported by Doctoral Scientific Research Starting Fundation of Liaoning Province(20121096) （20121096）
