解放军医学院学报Issue(12)：1209-1212,4.DOI:10.3969/j.issn.2095-5227.2013.12.002
经典型与劳力性热射病动物模型之比较
Comparison between classic and exertional animal models of heat stroke
摘要
Abstract
Objective To compare the classic and exertional animal models of heat stroke.Methods Thirty male SD rats were randomly divided into control group, classic heat stroke (CHS) group, and exertional heat stroke (EHS) group (10 in each group). The rectal temperature, its time to reach 42.5℃, and serum creatine kinase (CK) level were measured. Lesions in their major organs were observed with H&E staining.Results The average onset time of heat stroke was significantly shorter whereas the serum CK level was significantly higher in EHS group than in CHS group (58.333±9.309 minvs 108.333±23.166 min, 4 444.44±1 287.915 U/Lvs 1 208.217±192.802 U/L,P<0.01). However, no significant difference was observed in mortality between the two groups (P>0.05). The lesions of major organs (small intestine, kidneys, and skeletal muscle) were significantly severer in EHS group than in CHS group.Conclusion The function of different organs is impaired much rapider and severer in exertional animal model of heat stroke than in classic animal model of heat stroke at its early stage.关键词
热射病/动物模型/死亡率/肌酸激酶Key words
heatstroke/animal model/mortality/creatine kinase分类
医药卫生引用本文复制引用
张婷,宋青,周飞虎,陈洁坤,苗利辉,吴振华..经典型与劳力性热射病动物模型之比较[J].解放军医学院学报,2013,(12):1209-1212,4.基金项目
国家自然科学基金项目(81050005) Support by the National Science Foundation of China(81050005) （81050005）
