解放军医学院学报Issue(12)：1248-1251,4.DOI:10.3969/j.issn.2095-5227.2013.12.016
正加速度对冠状动脉狭窄小型猪模型心肌显微结构的影响
Effect of positive acceleration on myocardial microstructure of miniature swine with coronary stenosis
摘要
Abstract
Objective To study the effect of positive acceleration (+Gz) on myocardial microstructure of miniature swine with coronary stenosis.Methods A left anterior descending coronary stenosis model of Bama miniature swine was established. Theflight environment was simulated. The maximum +Gz tolerance was measured. The microstructure of left ventricular anterior wall tissue sample taken from the swine was observed under light microscope and electron microscope, respectively.Results Light microscopy showed that the endocardium was well linked to myocardium and the myocardial cells were tightly arranged with no interstitial edema in sham operation group, the myocardial cells were partly deformed with slightly enlarged space and mild interstitial edema in mild stenosis group, the endocardial cells were edematous and the myocardial cells were irregularly arranged and ruptured with widely enlarged space in moderate stenosis group, the myocardial cells were significantly deformed and disarranged with significantly enlarged space and even deformed or exfoliated nuclei in severe stenosis group. Electron microscopy showed that the myocardialfibers and mitochondria were regularly arranged in sham operation group, the myocardialfibers were slightly blurred with accumulation of mitochondria and unclear inner ridge in mild stenosis group, the myocardialfibers were blurred with accumulation of mitochondria and vacuolation in moderate stenosis group, the myocardial fibers were ruptured and the mitochondria were severely deformed with concentrated cristae and some broken mitochondria in severe stenosis group.Conclusion The ventricular microstructure does not change significantly in miniature swine with mild coronary stenosis but changes significantly in those with moderate and severe stenosis at the maximum +Gz tolerance.关键词
加速度/冠心病/心肌组织/显微结构/巴马猪Key words
acceleration/coronary disease/myocardial tissue/microstructure/Bama pig分类
医药卫生引用本文复制引用
李亚平,张海涛,罗惠兰..正加速度对冠状动脉狭窄小型猪模型心肌显微结构的影响[J].解放军医学院学报,2013,(12):1248-1251,4.基金项目
全军“十二五”重点课题(BWS11J054) Suppored by the 12th Five Years Key Programs of Chinese PLA(BWS11J 054) （BWS11J054）
