解放军医学院学报Issue(3)：238-240,254,4.DOI:10.3969/j.issn.2095-5227.2014.03.012
PL-11两种诱导剂监测健康人服用氯吡格雷后的血小板功能变化
Role of PL-11 inducers in monitoring platelet function in healthy subjects after taking clopidogrel
关杰 1李莉 1朱远 1任军伟 1李艳燕 2黎晓辉 1白洁 1邓新立 1丛玉隆1
作者信息
- 1. 解放军总医院 南楼检验科，北京 100853
- 2. 兵器工业北京北方医院，北京 100089
- 折叠
摘要
Abstract
Objective To assess the role of PL-11 inducers in monitoring platelet function in healthy subjects after taking clopidogrel. Methods The role of PL-11 inducers, ADP and collagen, in monitoring platelet function in healthy subjects after taking clopidogrel was compared with light turbidimetric analysis (LTA) as its reference. Results The platelet function decreased in 25 healthy male young subjects with a mean age of 27.5±3.7 years 6 days after taking clopidogrel. The baseline value for PL-11 inducer collagen, LTA and PL-11 inducer ADP was 65.9%-89.1% (95%PI), 67.2%-86.8% (95%PI), 64.7%-83.6% (95%PI), respectively. An overlapped value was found before and after taking clopidogrel. ADP was correlated with LTA (r=0.757, P<0.001) and collagen (r=0.764, P<0.001), collagen was correlated with LTA (r=0.521, P=0.009). The baseline value of LTA was at least 10%lower after taking clopidogrel than before taking clopidogrel, which could thus be used as the criterion for clopidogrel reactivity. ROC analysis showed that the cut-off value for ADP and collagen was 66%and 60.0%, respectively. The sensitivity and specificity of ADP and collagen were 84.6%and 88.2%, 69.2%and 70.6%, respectively. Conclusion The sensitivity of ADP is higher than that of collagen in monitoring the platelet function in healthy subjects after taking clopidogrel. The sensitivity of LTA and ADP is interchangeable, and can thus become a classic light turbidimetry for platelet function monitoring.关键词
氯吡格雷/PL-11血小板功能检测仪/光比浊法/二磷酸腺苷/胶原Key words
chopidogrel/PL-11/platelet function detector/turbidimetric determination/adenosine diphosphate/collagen分类
医药卫生引用本文复制引用
关杰,李莉,朱远,任军伟,李艳燕,黎晓辉,白洁,邓新立,丛玉隆..PL-11两种诱导剂监测健康人服用氯吡格雷后的血小板功能变化[J].解放军医学院学报,2014,(3):238-240,254,4.
