摘要
Abstract
Objective To analyze the efficacy of terminal pro-brain natriuretic peptide (NT-ProBNP) for the state of illness monitoring in children combined with mycoplasma pneumonia and myocardial damage .Methods 62 children combined with mycoplasma pneumonia and myocardial damage were divided into non-heart failure group (14 cases) ,mild heart failure group (19 cases) ,moderate heart failure group (20 cases) and severe heart failure group (9 cases) ,according to ROSS cardiac functional grading standards .NT-proBNP ,cardiac troponin I (cTnI) ,creat-inkinase isoenzyme MB (CK-MB) ,high-sensitive Creaction protein (hs-CRP) and left ventricular ejection fraction (LVEF) and ratio of early diastolic flow velocity at mitral valve and Mitral annular early diastolic myocardial velocity (E/E′) were examined .Results NT-ProBNP level in mild heart failure group was significantly higher than non-heart failure group (P<0 .05) .cTnI and hs-CRP levels in moderate heart failure group were higher than non-heart failure group (P<0 .05) ,and levels of CK-MB and NT-ProBNP were significantly different with those in non-heart failure group and mild heart failure group (P< 0 .05) .cTnI and CK-MB levels in severe heart failure group were higher than non-heart failure group and mild heart failure group (P<0 .05) ,hs-CRP level was higher than non-heart failure group (P<0 .05 ) ,and NT-ProBNP level was higher than non-heart failure group ,mild heart failure group and moderate heart failure group (P<0 .05) .LVEF and E/E levels in mild heart failure groups were different with those in non-heart failure group (P<0 .05) .LVEE level in moderate heart failure group was different with that in non-heart failure group (P< 0 .05) ,and E/E′ level was different with non-heart failure group and mild heart failure group (P<0 .01 ,P<0 .05) .E/E′level in severe heart failure groups was different with non-heart failure group and mild heart failure group (P<0 .05) .NT-ProBNP was more sensitive and specific for the diagnosis of heart failure caused by Mycoplasma pneumoniae (MP) infection than cTnI ,CK-MB ,hs-CRP and LVEF+E/E′.Conclusion NT-ProBNP might be helpful for the early diagnosis and illness state judgment of heart failure in children combined with MP infection and myocardial damage .关键词
支原体肺炎/心肌损害/心衰/N-末端脑钠素原Key words
Mycoplasma pneumonia/myocardial damage/heart failure/NT-ProBNP
