检验医学与临床Issue(17)：2283-2285,3.DOI:10.3969/j.issn.1672-9455.2013.17.036
脑小血管病的轻度认知障碍与血浆同型半胱氨酸的关系研究
Relationship between plasma homocysteine and mild cognitive impairment in patients with cerebral small vessel disease
摘要
Abstract
Objective To explore the relationship between plasma homocysteine (Hcy) and vascular mild cog-nitive impairment (VMCI) in patients with cerebral small vessel disease (SVD) .Methods Plasma Hcy ,folic acid and VitB12 were determined in 82 cases of VMCI patients with cerebral SVD (VMCI group) and 60 healthy subjects (control group) ,who were scored with Montreal Cognitive Assessment (MoCA) .Correlation between plasma Hcy level and MoCA scores was analyzed .Results Plasma Hcy level in VMCI group was significantly higher than that in control group (P<0 .01 ) ,but plasma levels of folic acid and VitB12 ,MoCA total score and MoCA subscore with re-gard to composition of the cube ,clock drawing test ,recognition of target digit and delayed recall were lower than control group (P<0 .01 ) .Plasma Hcy level was negatively correlated with plasma level of folic acid and VitB 12 and MoCA total score in VMCI group (P<0 .05) .Conclusion Increased plasma level of Hcy could be closely related to cognitive impairment in patients with cerebral SVD ,and cognitive of abstract space configuration and attention might be decreased earlier in patients with VMCI .关键词
脑小血管病/血管性轻度认知损害/同型半胱氨酸/蒙特利尔认知评估量表Key words
cerebral small vessel disease/vascular mild cognitive impairment/homocysteine/Montreal Cognitive Assessment引用本文复制引用
李霞绯,陈登容,吴娟..脑小血管病的轻度认知障碍与血浆同型半胱氨酸的关系研究[J].检验医学与临床,2013,(17):2283-2285,3.
