检验医学与临床Issue(19)：2513-2514,2517,3.DOI:10.3969/j.issn.1672-9455.2013.19.007
舒芬太尼鞘内注射用于腰硬联合阻滞分娩镇痛安全剂量的探讨
Safe dose of intrathecal injected sufentanil for the combined spinal-epidural anesthesia in delivery analgesia *
摘要
Abstract
Objective To discuss the efficacy and safety of different doses of intrathecal sufentanil in combined spinal-epidural anesthesia for delivery analgesia .Methods A total of 150 pregnant women were randomly divided in-to group A - E ,giving sufentanil for dosage of 6 .0 ,7 .0 ,8 .0 ,9 .0 and 10 .0 μg for combined spinal-epidural analgesia . PCA pump was activated ,when VAS ≥ 3 .Epidural medication was 0 .143% ropivacaine mesylate and 0 .3 μg/mL sufentanil .Analgesic onset time ,labor analgesia satisfaction ,first delivery analgesia duration ,adverse reaction and so on were compared between different groups .Results Analgesic onset time ,labor analgesia satisfaction ,neonatal plas-ma concentrations ,Apgar score of neonates and blood drug level in neonates were not statistically different between the 5 groups (P> 0 .05) .The first delivery analgesia duration and umbilical cord blood serum concentrations in group E were statistically different with other groups (P< 0 .05) .Conclusion The first time intrathecal injection of sufen-tanil should be 7-8 μg to obtain optimal delivery analgesia effect and protect the safety of puerpera and neonate .关键词
舒芬太尼/分娩镇痛/腰硬联合阻滞Key words
sulfentanil/delivery analgesia/combined spinal-epidural anesthesia引用本文复制引用
幸吉娟,劳诚毅,全伟斌,周朝明..舒芬太尼鞘内注射用于腰硬联合阻滞分娩镇痛安全剂量的探讨[J].检验医学与临床,2013,(19):2513-2514,2517,3.基金项目
广西壮族自治区南宁市重大科技攻关与新产品试验项目（201001025C ）。 （）
