检验医学与临床Issue(19)：2532-2533,2.DOI:10.3969/j.issn.1672-9455.2013.19.016
2型糖尿病血糖控制水平与并发糖尿病肾病的风险研究
Relationship between control of blood glucose level and the risk of diabetic nephropathy in type 2 diabetic mellitus
曹利蓉 1史清海 2葛迪 2何雁 2冉继华 2刘正祥 2伏建峰2
作者信息
- 1. 乌鲁木齐铁路局疾病预防控制所，乌鲁木齐 830011
- 2. 兰州军区乌鲁木齐总医院全军临床检验诊断中心，乌鲁木齐 830000
- 折叠
摘要
Abstract
Objective To investigate the relationship between the control of blood glucose level and the risk of diabetic nephropathy (DN ) in patients with type 2 diabetic mellitus (T2DM ) .Methods According to the level of glycosylated hemoglobin A1c (HbA1c) ,T2DM patients were assigned into 2 groups ,including tight blood glucose control group (HbA1c ≤ 7 .0% ,n= 72) and loose blood glucose control group (HbA1c > 7 .0% ,n= 32) .Serum levels of cystatin C (Cys C) ,creatine(Cr) ,urea ,high sensitive C-reactive protein (hs-CRP) and urinary concentrations of retinol-binding protein (U-RBP) ,microalbumine (U-mAlb) were measured respectively .Results Serum levels of Cys C ,hs-CRP ,U-RBP and U-mA1b in all diabetic groups were significantly higher than control group (P< 0 .05) , and worse blood glucose control could lead to higher level of serum Cys C ,hs-CRP ,U-RBP and U-mA1b(P< 0 .05) . Conclusion The higher levels of HbA1c in patients T2DM ,the higher risk of DN .Efficient control of blood glucose level could be important to prevent and postpone the incidence of DN in patients with T 2DM .关键词
2 型糖尿病/并发症/糖化血红蛋白/糖尿病肾病风险Key words
type 2 diabetic mellitus/complications/glycosylated hemoglobin/risk of diabetic nephropa-thy引用本文复制引用
曹利蓉,史清海,葛迪,何雁,冉继华,刘正祥,伏建峰..2型糖尿病血糖控制水平与并发糖尿病肾病的风险研究[J].检验医学与临床,2013,(19):2532-2533,2.
