检验医学与临床Issue(19)：2564-2565,2.DOI:10.3969/j.issn.1672-9455.2013.19.033
尼古丁对大鼠椎间盘内细胞因子表达的影响及意义
Influencing of nicotine on the expression of IL-1β and IL-1R Ⅰ in intervertebral disc of rats
李左安 1张旭鸣1
作者信息
- 1. 福建省立医院/福建医科大学省立临床医学院，福州 350001
- 折叠
摘要
Abstract
Objective To investigate the influencing of nicotine on the expression of interleukin (IL)1 β (IL-1β) and IL-1 receptor Ⅰ (IL-1R Ⅰ ) in intervertebral discs of rats .Methods Cigarette-smoking rats models with tow different quantity of cigarettes were established and the expression levels of IL -1β and IL-1R Ⅰ were detected on the 2 ,4 and 8 weeks after model construction ,and the results were compared with non-smoking rats .Results The posi-tive rates of IL-1β and IL-1R Ⅰ were (76 .00 ± 3 .24)% and (46 .00 ± 2 .79)% in high cigarettes quantity cigarettes group ,and those were (52 .00 ± 3 .91)% and (31 .00 ± 2 .29)% respectively in low cigarettes quantity group after 8 weeks of passive smoking , both of which were significantly higher than non-smoking group ( P < 0 .01 ) . Conclusion Passive-smoking could inducing the expression of IL-1βand IL-1R Ⅰ in intervertebral discs of rats , which might be related with time of smoking and quantity of cigarettes .The high expression of IL-1βand IL-1R Ⅰcould be related with the degeneration of intervertebral disc in rats .关键词
细胞因子白介素-1β/白介素-1 受体/被动吸烟/免疫组化Key words
IL-1β/IL-1R Ⅰ/passive smoking/immunohistochemisty引用本文复制引用
李左安,张旭鸣..尼古丁对大鼠椎间盘内细胞因子表达的影响及意义[J].检验医学与临床,2013,(19):2564-2565,2.
