检验医学与临床Issue(20)：2648-2649,2651,3.DOI:10.3969/j.issn.1672-9455.2013.20.004
142例血红蛋白H病患者血液学与分子生物学检测结果分析
Results analysis of hematology and molecular biology detection among 142 patients with characters in 142 patients with hemoglobinHdisease
摘要
Abstract
Objective To analyze the results of hematology and molecular biology detection in patients with hemoglobin H(HbH) disease .Methods Results of capillary electrophoresis(CE) detection and related hematology a-nalysis were analyzed in 142 patients with HbH disease in rural areas of Nanning ,definitely diagnosed by molecular biology detection .Results In 142 patients with HbH disease ,89 cases were with deletion HbH disease ,accounting for 62 .68% ,while 53 cases were with non-deletion HbH disease ,accounting for 37 .32% .CE detection of patients with deletion HbH disease showed a HbH peak ,of patients combined with HbH and HbCS disease showed a HbH peak and a HbCS peak at the same time .Hemoglobin electrophoresis and hematology analysis indicated that HbH level was higher and disease condition of anaemia was more severe in patients with non-deletion HbH disease than in patients with deletion HbH disease(P<0 .05) .Conclusion The gene mutation types in patients with HbH disease of rural areas of Nanning could be various ,most of which might be deletion type .Specific HbCS peak could be detected in patients combined with HbCS and HbH disease by CE detection .High level of HbH and the aggregation of CS chain on membrane of red blood cells could be the main reasons ,causing the disease condition of patients combined with HbCS and HbH is severe than patients with deletion HbH disease .关键词
血红蛋白 H病/毛细管电泳/血液学特点Key words
hemoglobin H disease/capillary electrophoresis/hematology characteristics引用本文复制引用
阮丽明,周艳洁,朱茂灵,丁进龙,何桂琼,梁萧..142例血红蛋白H病患者血液学与分子生物学检测结果分析[J].检验医学与临床,2013,(20):2648-2649,2651,3.基金项目
广西卫生厅自筹基金项目（Z ．2010014）桂人口计生研（01-2010-001）。 （）
