钟一鸣 1谷秀梅 1刘文恩 1龚志军 1李艳明 1陈丽华1
作者信息
- 1. 中南大学湘雅医院检验科，长沙 410008
- 折叠
摘要
Abstract
Objective To investigate the clinical diagnostic value of combined detection of procalcitonin (PCT) ,C-reactive protein(CRP) ,white blood cell count(WBC) and platelet(PLT) in early diagnosis of neonatal sep-sis .Methods PCT ,CRP ,WBC and PLT were detected in 37 cases with sepsis(sepsis group) ,36 cases with local in-fection(local infection group) and 30 non-infection cases(non-infection group) .Results The levels of serum PCT and CRP in sepsis group before treatment were significantly higher than local infection group and non-infection group (P<0 .01) ,and there was positive correlation between the two indicators (P<0 .05) .Effective therapy could signifi-cantly reduce serum levels of PCT and CRP(P<0 .01) .Levels of WBC and PLT in three groups were without statis-tical difference(P>0 .05) .The sensitivity ,specificity ,positive predictive value ,negative predictive value ,Youden in-dex and positive likelihood ratio of PCT were 89 .2% ,90 .0% ,91 .7% ,87 .1% ,0 .79 and 8 .92 respectively ,which were the highest in the four indicators .The specificity and positive predictive value of combined detection of PCT , CRP ,WBC and PLT were 100% .The area under the receiver operating characteristic (ROC) curve of PCT ,CRP , WBC and PLT were 0 .970 ,0 .733 ,0 .580 and 0 .621 ,respectively .Conclusion Combined detection of PCT ,CRP , WBC and PLT could improve the specificity of early diagnosis of neonatal sepsis ,with higher diagnostic value than separate detection .关键词
新生儿败血症/降钙素原/C-反应蛋白/白细胞计数/血小板Key words
neonatal sepsis/procalcitonin/C-reactive protein/white blood cell count/platelet
