检验医学与临床Issue(20)：2679-2680,2682,3.DOI:10.3969/j.issn.1672-9455.2013.20.019
法舒地尔对合并肺动脉高压慢性阻塞性肺疾病加重期患者炎性因子的影响
Influence of fasudil on inflammatory factors in patients combined with COPD exacerbation and pulmonary hypertension
王昌锋 1吴雪花 1张华希1
作者信息
- 1. 湖北省黄冈市中心医院呼吸内科 438000
- 折叠
摘要
Abstract
Objective To investigate the function of fasudil in patients with chronic obstructive pulmonary dis-ease(COPD) with pulmonary hypertension .Methods Sixty-eight patients with COPD and pulmonary hypertension were randomly divided into control group ,receiving routine therapy ,and treatment group ,receivig routine therapy and fasudil treatment .Pulmonary pressure and serum tumor necrosis facto α(TNF-α) ,interleukin-8(IL-8) and C reaction protein(CRP) levels were detected before and after treatment .Results After treatment ,pulmonary pressure in treat-ment group was lower than control group(P<0 .05) .In treatment group ,serum levels of TNF-α,IL-8 and CRP were significantly decreased after treatment (P<0 .05) .Pulmonary pressure in treatment group was positively correlated with TNF-α,IL-8 and CRP level(P<0 .05) .Conclusion Treatment of fasudil in patients with COPD and pulmonary hypertension coud reduce pulmonary pressure and TNF-α,IL-8 ,CRP levels ,and pulmonary pressure might be corre-lated with inflammatory factors .关键词
慢性阻塞性肺疾病/肺动脉高压/法舒地尔/肿瘤坏死因子α/白细胞介素8/C反应蛋白Key words
chronic obstructed pulmonary disease/pulmonary hypertension/fasudil/tumor necrosis fac-tor/interleukin-8/C reaction protein引用本文复制引用
王昌锋,吴雪花,张华希..法舒地尔对合并肺动脉高压慢性阻塞性肺疾病加重期患者炎性因子的影响[J].检验医学与临床,2013,(20):2679-2680,2682,3.
