检验医学与临床Issue(22)：2939-2942,4.DOI:10.3969/j.issn.1672-9455.2013.22.002
动脉粥样硬化性肾动脉狭窄介入治疗与药物治疗的临床分析
The clinical comparison of interventional therapy with medicine therapy for atherosclerotic renal artery stenosis
摘要
Abstract
Objective Atherosclerotic renal artery stenosis (ARAS) is closely related to cardiovascular disea-ses .Interventional therapy can relieve artery stenosis ,but clinical effects have been challenged .Through strict control indications for interventional treatment ,this research aims to evaluate the clinical curative effects between ARAS pa-tients treated with drugs only and patients treated with drugs combined with intervention .Methods 120 patients who were diagnosed as ARAS and renal artery stenosis area ≥70% have been recruited during the period of January 2010 to January 2011 .Through comprehensive evaluations of kidney (renal size ,renal artery stenosis degree ,the ipsilateral glomerular filtration rate ,pressure gradients across renal artery stenosis ) and clinical complications ,patients have been divided into drug therapy group (patients refused interventional therapy ) and drug therapy combined with inter-ventional therapy group .Patients'blood pressure ,serum creatinine ,cardiac function ,cardiovascular events and read-mission times were recorded before and after treatment .The followed up was one year .Results In the 120 patients , 48 cases were in interventional group ,72 cases were in drug group .In interventional group ,the blood pressure im-proved significantly (P<0 .01) ,3 patient were cured ,24 patients blood pressure improved ,21 cases were invalid . There were no significant difference in the number of antihypertensive drug (P>0 .05) ,average serum creatinine re-duced mildly ;Drug group needed to take more drugs to control blood pressure ,and average serum creatinine elevated mildly .While in the group of ARAS patients combined with heart failure ,interventional therapy can improve heart function of patients with heart failure ,reduce the number of hospitalizations due to heart failure ,angina and pulmona-ry edema within 1 year .Conclusion Intervention combined with drug therapy and drug therapy alone can both effec-tively control blood pressure ,however the patients in intervention combined with drug therapy team after treatment take fewer antihypertensive drugs .Compared to drug therapy ,intervention combined with drug therapy can signifi-cantly improve patients'cardiac function ,reduce the readmission caused by heart failure ,angina and pulmonary edema of patients with ARAS and heart failure .However ,there was no significant effect on Serum creatinine between the two groups .关键词
动脉粥样硬化/肾动脉狭窄/心衰Key words
Atherosclerosis/Renal artery stenosis/Heart failure引用本文复制引用
汤曾耀,郑泽琪,梅寒颖,黄鑫,王琦,曹原,刘继文..动脉粥样硬化性肾动脉狭窄介入治疗与药物治疗的临床分析[J].检验医学与临床,2013,(22):2939-2942,4.基金项目
江西省卫生厅重大招标（20104001）。 （）
