检验医学与临床Issue(23)：3122-3124,3.DOI:10.3969/j.issn.1672-9455.2013.23.017
大理白族2型糖尿病与脂联素基因多态性相关性分析
Genetic association analysis of the adiponectin polymorphisms in type 2 diabetes of Bai nationality at Dali area
摘要
Abstract
Objective Adiponectin gene is associated with BMI ,insulin sensitivity and diabetes .To detect the impact of adiponectin gene promoter single nucleotide polymorphism (SNP) on type Ⅱ diabetes in Bai nationality of Yunnan province .Methods We detected adiponectin gene + 276G/T and + 45T /G with PCR- direct sequencing in 300 cases of unrelated people which contain healthy control subjects (n= 120) and type 2 diabetic patients(n= 180) in Bai nationality of Yunnan province ,then analyzed their relationship with type 2 diabetes .Results SNP + 45(G/T ) showed significant difference of allele frequencies between type 2 diabetic group and the control group(P= 0 .013) . Not statistically significant difference was found at adiponectin gene polymorphisms + 276G/T in this study .Linkage disequilibrium(LD) of + 276G/T and + 45T /G between cases and controls showed significant differences .Conclusion The present study provides evidence that SNP + 45G in exon 2 region of the adiponectin gene contributes to the de-velopment of type 2 diabetes in Bai nationality of Yunnan province .关键词
脂联素基因/单核苷酸多态性/2 型糖尿病/大理白族Key words
adiponectin gene/single nucleotide polymorphism/type 2 diabetes/Bai nationality引用本文复制引用
康庄,苏恒,张云,虞艳芳,欧杨,薛元明,赵惠珠..大理白族2型糖尿病与脂联素基因多态性相关性分析[J].检验医学与临床,2013,(23):3122-3124,3.基金项目
云南省卫生厅内设机构科研资助项目（2009NS015）；中华医学会临床医学科研专项资金（10020130235）。 （）
