摘要
Abstract
Objective To investigate serum a-l-glycosidase(AFU) ,golgi glycoprotein 73(GP73) and alpha-fe-toprotein(AFP) in the diagnosis of primary hepatic carcinoma (PHC) clinical significance .Methods The rate of chemical colorimetric method ,method of enzyme-linked immune adsorbent (ELISA ) and direct chemiluminescence method were used to detect serum AFU ,GP73 and AFP level in 38 patients with PHC ,42 patients with benign liver diseases and 50 cases in normal control group ,then compared the datas in the three groups .Results Serum AFU , GP73 ,AFP level of PHC patients[(789 .4 ± 475 .2) mol/L ,(205 .5 ± 50 .8)μg/L ,(977 .3 ± 637 .4)ng/mL] ,were higher than those in the liver benign disease group(378 .3 ± 127 .9)mol/L ,(77 .5 ± 28 .9)μg/L ,(6 .09 ± 1 .57)ng/mL and the normal control group [(347 .8 ± 119 .6) mol/L ,(33 .5 ± 7 .5)μg/L ,(4 .17 ± 1 .26)ng/mL] ,the difference was statistically significant(P< 0 .01) .The sensitivity and specificity of serum AFU ,GP73 ,AFP levels as indicators to detect PHC were 75 .1% ,73 .4% ,62 .2% ;86 .8% ,67 .5% ,97 .8% ,the sensitivity and specificity of the united three test were 93 .4% ,85 .4% respectively .Conclusion The united three test can increase the rate of positive detection , which is beneficial to diagnosis of PHC ,discriminate course of the disease ,and observte the effect of treatment .关键词
血清a-l-岩藻糖苷酶/高尔基体糖蛋白/甲胎蛋白/原发性肝癌/联合检测Key words
serum a-l-glycosidase/golgi glycoprotein/alpha-fetoprotein/primary hepatic carcinoma/combined detection
