检验医学与临床Issue(5)：595-596,600,3.DOI:10.3969/j.issn.1672-9455.2014.05.007
抗病毒治疗对HBeAg阴性慢性乙型肝炎患者外周血T淋巴细胞亚群状态的影响
The effects of anti-hepatitis B virus treatment on the variations of T-lymphocyte subsets in peripheral blood of HBeAg- negative chronic hepatitis B patients
刘小琴1
作者信息
- 1. 重庆市垫江县人民医院感染科 408300
- 折叠
摘要
Abstract
Objective To investigate the variation of T lymphocyte subsets in peripheral blood of patients with HBeAg-negative chronic hepatitis B after the treatment of Lamivudine .Methods Folw cytometry was used to detect the CD4+ ,CD8+ T cell ,liver function and HBV-DNA in 70 patients with HBeAg-negative chronic hepatitis B .These indicators were detected again after 24 weeks therapy of Lamivudine .Results The percentage of CD4+ T cell was lower ,but higher in CD8+ T cells ,and both had statistical differences compared with controls (P<0 .05) .After the antiviral therapy by Lamivudine for 24 weeks ,the expression of HBV-DNA ,ALT and AST significantly degraded and the clinical symptoms also improved ,furthermore the expression of CD4+ T cell obviously increased(P<0 .05) .Con-clusion T-lymphocyte palyed extremely important role in the course of disease with HBeAg-negative chronic hepati-tis B patients and anti-hepatitis B virus treatment could enhance cellular immunity of the patients ,and improve the ex-pression of T-lymphocyte subsets .关键词
慢性乙型肝炎/T淋巴细胞亚群/拉米夫定Key words
chronic hepatitis B/T-lymphocyte subsets/lamivudine引用本文复制引用
刘小琴..抗病毒治疗对HBeAg阴性慢性乙型肝炎患者外周血T淋巴细胞亚群状态的影响[J].检验医学与临床,2014,(5):595-596,600,3.
