检验医学与临床Issue(6)：739-741,3.DOI:10.3969/j.issn.1672-9455.2014.06.008
综合ICU呼吸机相关性肺炎病原菌分布及耐药性研究
Study on pathogens and drug resistance of ventilator-associated pneumonia in comprehensive intensive care unit
贾晓君 1易玲娴 1张长春 1张淑敏1
作者信息
- 1. 解放军306医院重症监护室，北京 100101
- 折叠
摘要
Abstract
Objective To determine the distribution and drug resistance characteristic of pathogens in patients of comprehensive intensive care unit (ICU) with ventilator-associated pneumonia (VAP) ,and to provide evidence for rational suage of antibiotics .Methods A total of 122 patients receiving mechanical ventilation over 48 h were selected from January 2012 to December 2012 in this comprehensive ICU and the characteristic of pathogens and their drug resistance were retrospectively analyzed .Results Among 122 patients with mechanical ventilation ,55 cases were di-agnosed as VAP ,accounting for 45 .08% .Among 122 strains of pathogens collected ,78 strains were Gram-negative bacteria which accounted for 63 .93% .The most three pathogens were Acinetobacter baumanii ,Klebsiella pneumoniae and Pseudomonas aeruginosa ,with 4 strains of Klebsiella pneumoniae were found expressing extended spectrum beta-lactamases (ESBL) .19 strains of Gram-positive bacteria were isolated ,accounting for 15 .57% .The primary gram-positive bacteria was Staphylococcus aureus ,in which 1 strain was resistant to vancomycin .25 strains of fungi were i-solated ,accounting for 20 .49% ,mainly of which was Candida albicans .The Gram-negative bacteria were resistant to ampicillin ,ciprofloxacin ,imipenem ,ceftriaxone and unasyn obviously .Compared with ESBL negative Klebsiella pneu-moniae ,ESBL positive strains were resistance to the vast majority of antibiotics ,but were relatively sensitive to imi-penem and piperacillin/methimazole .Conclusion The primary pathogens of VAP could be Gram-negative bacteria in this comprehensive ICU .The analysis of pathogen and its drug resistance in VAP could provid evidence for the ra-tional usage of antibiotics for treating VAP .关键词
呼吸机相关性肺炎/病原菌/耐药性Key words
ventilator-associated pneumonia/pathogen/drug resistance引用本文复制引用
贾晓君,易玲娴,张长春,张淑敏..综合ICU呼吸机相关性肺炎病原菌分布及耐药性研究[J].检验医学与临床,2014,(6):739-741,3.
