检验医学与临床Issue(6)：749-751,3.DOI:10.3969/j.issn.1672-9455.2014.06.012
人血清附睾蛋白4和糖类抗原125联合检测对卵巢癌的诊断价值
Values of serum human epididymis protein 4 and carbohydrate antigen 125 in the diagnosis of ovarian cancer
陈宗波 1陈展泽 2李国选 1周碧芸 1刘伟旗 3李子萍4
作者信息
- 1. 广东省佛山市南海经济开发区人民医院 528234
- 2. 广东省佛山市第一人民医院 528000
- 3. 广东省佛山市禅城区中心医院 528000
- 4. 广东省佛山科学技术学院医学院 528000
- 折叠
摘要
Abstract
Objective To explore the values of serum human epididymis protein 4 (HE4) and carbohydrate antigen 125 (CA125) in the diagnosis of ovarian cancer .Methods Serum levels of HE4 and CA125 were detected in 91 patients with ovarian cancer ,69 patients with benign ovarian diseases and 60 healthy females by using chemilumi-nescence immune assay .Results Serum levels of HE4 and CA125 in patients with ovarian cancer were significantly higher than patients with benign ovarian diseases and healthy subjects (P<0 .01) .The sensitivity ,specificity and di-agnostic performance of HE4 were higher than CA125 ,when being detected alone .Combined assay of parallel test of HE4 and CA125 could improve sensitivity and Combined assay of series test could improve specificity .Compared with individual and combined assay ,the positive detection rate of parallel test was higher .With the elevating of staging of ovarian cancer ,serum levels of HE4 and CA125 were also elevated .But there was no significant difference of serum CA125 level between patients with ovarian cancer at stage Ⅰand patients with benign ovarian tumors (P>0 .05) . Conclusion Compared with CA125 ,HE4 could be the best single tumor marker for diagnosis of ovarian cancer . Combined assay of parallel test could improve the diagnostic sensitivity and combined assay of series test could im-prove the diagnostic specificity .关键词
血清附睾蛋白4/糖类抗原125/联合检测/卵巢癌Key words
human epididymis protein 4/carbohydrate antigen 125/combined assay/ovarian cancer/diagnostic value引用本文复制引用
陈宗波,陈展泽,李国选,周碧芸,刘伟旗,李子萍..人血清附睾蛋白4和糖类抗原125联合检测对卵巢癌的诊断价值[J].检验医学与临床,2014,(6):749-751,3.
