检验医学与临床Issue(8)：1013-1015,3.DOI:10.3969/j.issn.1672-9455.2014.08.003
降钙素原在新生儿感染性疾病中的临床价值
Diagnostic value of procalcitonin for neonatal infections
摘要
Abstract
Objective To explore the clinical significance of serum procalcitonin (PCT ) for neonatal infec-tions .Methods A total of 223 cases of neonatal patients ,including 43 cases of sepsis ,89 cases of local infection and 59 cases of non-bacterial infection ,treated in Department of Neonatology from March 2009 to August 2012 ,and 32 cases of healthy newborns were enrolled .Serum levels of PCT were compared between each group ,and receiver oper-ating characteristic (ROC) curve was prepared to evaluate the diagnostic value of PCT .Results Serum levels of PCT in non-bacterial infection group ,local bacterial infection group and sepsis group were (0 .22 ± 0 .23) ,(1 .16 ± 1 .25) and (13 .85 ± 6 .54) ng/mL separately ,which were all higher than the (0 .22 ± 0 .29)ng/mL of healthy control group . Serum levels of PCT in local infection group and sepsis group were positively correlated with the amount of white blood cells (WBC) .Taking 0 .95 ng/mL as cut-off value ,the sensitivity and specificity of PCT for the diagnosis of neonatal infections were 95 .3% and 93 .7% .When bacterial infections were controlled ,serum levels of PCT de-creased quickly to normal range ,which was superior to WBC .Conclusion PCT could be used as indicator for early diagnosis of neonatal infections ,and dynamic monitoring of PCT level might be helpful for evaluation of curative effect and guiding clinical medication .关键词
降钙素原/新生儿/感染Key words
procalcitonin/neonatal/infection引用本文复制引用
宋鉴清,周雯雯,满东亮,杨志东,丁奇..降钙素原在新生儿感染性疾病中的临床价值[J].检验医学与临床,2014,(8):1013-1015,3.基金项目
辽宁省自然科学基金资助项目（201102291）。 （）
