摘要
Abstract
Objective To explore the effect of chemotherapy on glycated hemoglobin and fasting plasma glu-cose in patients with malignant tumors .Methods A total of 50 patients with malignant tumor ,treated in this hospital between January 2010 and December 2011 ,were enrolled ,including 7 patients with previously diagnosed diabetes be-fore chemotherapy .Fasting plasma glucose and glycated hemoglobin were detected before and after the first time of chemotherapy .Results After chemotherapy treatment ,among 43 patients without previously diagnosed diabetes ,22 patients (51 .1% ) were with elevated fasting plasma glucose level ,11 cases (25 .6% ) were with elevated glycated he-moglobin and 10 cases (23 .3% ) were diagnosed as diabetes .After chemotherapy treatment ,among 7 patients with previously diagnosed diabetes ,6 cases were with both elevated fasting plasma glucose and glycated hemoglobin level . After the first time of chemotherapy ,levels of glycated hemoglobin in patients with or without previously diagnosed diabetes were both higher than levels detected before chemotherapy (P<0 .05) .In patients without previously diag-nosed diabetes ,levels of glycated hemoglobin ,detected before the second ,seventh and eighth cycle of chemotherapy , were apparently higher than that detected before the first cycle ,and levels of fasting plasma glucose ,detected before the fourth cycle ,were evidently higher than those detected before the first chemotherapy ( P < 0 .05 ) . Conclusion Chemotherapy could cause the elevation of fasting plasma glucose and glycated hemoglobin levels in part of patients with malignant tumor ,and combined detection of fasting plasma glucose and glycated hemoglobin might be helpful for the identification of potential diabetes .关键词
糖化血红蛋白/空腹血糖/化疗/恶性肿瘤Key words
glycated hemoglobin/fasting plasma glucose/chemotherapy/malignant tumor
