昆明医科大学学报Issue(1)：63-67,5.
帕金森氏病精神障碍的磁共振弥散张量研究
Study of Psychosis Associated with Parkinson Disease by Diffusion Tensor Imaging
摘要
Abstract
Objective Using 3.0T magnetic resonance imaging and diffusion tensor magnetic resonance imaging, quantitative analysis of nerve fibers in region of interest was conducted in patients with psychosis associated with parkinson disease (PDPsy), PD patients without psychotic symptoms and normal control group, then investigate the relationship between FA value change in the region of interest and PDPsy, and the pathogenesis of PDPsy. Methods Sixteen patients with PDPsy, 24 PD patients without psychotic symptoms and 20 healthy persons with the corresponding age and sex (normal control group) were enrolled in this study. The patients with PDPsy and patients without psychotic symptoms have the matched gender, age and disease duration. All patients were underwent routine MR plain scan and DTI scan. The FA graph was reestablished, and the FA values of the bilateral substantia nigra-striatum fiber loop through the site (substantia nigra, red nucleus, nucleus, globus pallidus), frontal, occipital lobe and cingulate associated with schizophrenia were statistical analyzed. Results The nigral FA values in PDPsy and PD groups were significantly lower than that in control group. The frontal lobe and occipital lobe FA values in PDPsy group were significantly lower than those in control group. The frontal lobe, occipital lobe and cingulate FA values in PDPsy group were lower than those in PD group, but there were no significant differences between the two groups. The frontal lobe and occipital lobe FA values in PD group were lower than those in the control group, but there were no significant differences between the two groups. Conclusion DTI is a noninvasive and quantitative measurement for FA values of various brain regions in patients with PDPsy. It can reveal the PDPsy corresponding neural loop changes at the molecular imaging level, and can provide more information for the pathogenesis and clinical manifestations of PDPsy.关键词
磁共振成像/弥散张量成像/帕金森氏病精神障碍Key words
Magnetic resonance imaging/Diffusion tensor imaging/Psychosis associated with parkinson disease分类
医药卫生引用本文复制引用
赵英,武绍远,吴昆华,钟静玫,王云勇,龚霞蓉,芮茂萍..帕金森氏病精神障碍的磁共振弥散张量研究[J].昆明医科大学学报,2014,(1):63-67,5.基金项目
云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 （）
