昆明医科大学学报Issue(2)：27-30,4.
3.0T MR磁敏感加权成像对早期帕金森病黑质致密带的研究
3.0T MR Susceptibility-weighted Imaging for Substantia Nigra Pars Compacta in Primary Parkinson’s Disease
摘要
Abstract
Objective To evaluate the application of measurement of T2*value,width of substantia nigra pars compacta (SNc) and the ratio of the width to the midbrain diameter in diagnosing Parkinson disease (PD) in early stage with susceptibility weighted imaging ( SWI) by 3T MR. Methods 59 patients with early stage idiopathic PD patients and 59 healthy controls,ranging in same ages and gender,had been scanned with routine sequences and SWI sequences by 3T MR. T2*value,width and the ratio of the width to the midbrain diameter of SNc were measured. The results of measurement were analyzed and compared. Results (1) The T2*values, width and the ratio of the width to the midbrain diameter was decreased in homolateral side SNc of symptoms of subjects with PD compared with the healthy controls ( <0.05) . (2) There was a significant reduction in the T2*values and the ratio of the width to the midbrain diameter in contralateral side SNc symptoms of subjects with PD compared with the healthy controls (P<0.05) . There was no differences in width of SNc ( >0.05) . Conclusion Measurement of T2*value, width and the ratio of the width to the midbrain diameter of SNc with SWI is reliable to diagnose PD.关键词
帕金森病/黑质致密带/脑铁沉积Key words
Parkinson’s disease/Substantia nigra pars compacta/Brain iron deposition分类
医药卫生引用本文复制引用
王波,安鸿飞,张洁,毕国力,吴昆华,任丽香,沈凌..3.0T MR磁敏感加权成像对早期帕金森病黑质致密带的研究[J].昆明医科大学学报,2014,(2):27-30,4.基金项目
云南省应用基础研究计划基金资助项目 （）
