昆明医科大学学报Issue(2)：48-51,4.
GM-CSF及其受体与早期自然流产的关系研究
Study of Relationship of GM-CSF and Its Receptor with Early Spontaneous Abortion
摘要
Abstract
Objective To investigate the relationship of Maternal-fetal interface local cytokine GM-CSF and its receptor with the occurrence of early spontaneous abortion. Methods From August 2009 to December 2011,we collected 30 villi tissue samples with artificial abortion and 30 villi tissue samples with spontaneous abortion. At the same time, we collected 30 villi tissue samples with artificial abortion and 30 decidua tissue samples with spontaneous abortion,and 30 decidua tissue samples with spontaneous abortion. The human chorionic gonadotropin ( HCG) was detected by radioimmunoassay in every group. The expressions of granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte-macrophage colony-stimulating factor receptor (GM-CSFR ) were detected by Immunohistochemical staining and Western Blot in the villi tissue and decidua tissue in every group. Results The concentration of HCG in the spontaneous abortion group was lower than that in the artificial abortion group ( <0.05) . The protein expressions of GM-CSF and GM-CSFR were found in villus and deciduas tissues in both groups. The protein expression levels of GM-CSFR in the villus tissues were higher in spontaneous abortion group than those in artificial abortion group ( <0.05), the protein expression of GM-CSF was upregulated, but there was no statistically significant difference between two groups. In deciduas tissues, the protein expressions of GM-CSF and GM-CSFR were upregualted in spontaneous abortion group ( <0.05) . Conclusions The suitable concentrations of GM-CSF and GM-CSFR in decidua tissue maintain the pregnancy continued. However,the higher concentrations of GM-CSF and GM-CSFR in the decidua tissue may be one of reasons of spontaneous abortion.关键词
GM-CSF/GM-CSFR/自然流产/人工流产Key words
Granulocyte-macrophage colony-stimulating factor/Granulocyte-macrophage colony stimulating factor receptor/Spontaneous abortion/Artificial abortion分类
医药卫生引用本文复制引用
柏青,李寅,杨一敏,姚伟林,孙建军,岳红萍..GM-CSF及其受体与早期自然流产的关系研究[J].昆明医科大学学报,2014,(2):48-51,4.基金项目
云南省科技厅应用基础研究基金资助项目 （）
