昆明医科大学学报Issue(2)：63-66,4.
长方案中长效与短效达菲林的垂体降调节效果比较
Comparative Study of Long-and Short-acting Triptorelin on Pituitary Down-regulation in Long Protocol
摘要
Abstract
Objective To explore the efficacy of long- and short-acting triptorelin on pituitary down-regulation in long protocol and the pregnancy outcome in vitro fertilization and embryo transfer (IVF-ET) . Methods Three hundred and seventeen patients for IVF-ET were enrolled as study and randomized them into two groups. In group A (n=145), patients received single dose subcutaneous injection of 1.25 mg long-acting diphereline in mid-luteal phase. In group B (n=172), patients received 0.1 mg/d subcutaneous injection of short-acting diphereline in mid-luteal phase for 14-18 days until pituitary suppression were got,and then reduced to 0.05 mg/d until the injection of HCG. Results The dose and the days of gonadotropin administration in group A were bigger and longer than those in group B ( <0.05) . There were no significant differences in the number of retrieved oocytes, fertilization rate,high quality embryos,implantation rate and clinical pregnancy rate between the two groups (all > 0.05) . But clinical pregnancy rate of group B had increasing trend. Conclusion Administration of short-acting diphereline has the similar effect with that of long-acting diphereline on pituitary down-regulation in long protocol. Short-acting diphereline requires lower amount of gonadotropin and is more flexible,so it should be recommended.关键词
达菲林/垂体降调节/体外受精Key words
Diphereline/Pituitary down-regulation/In vitro fertilization分类
医药卫生引用本文复制引用
李东娅,孟昱时,马兰,杨晓玲,镡颖,杨洁..长方案中长效与短效达菲林的垂体降调节效果比较[J].昆明医科大学学报,2014,(2):63-66,4.基金项目
云南省卫生厅内设机构研究基金资助项目 （）
