昆明医科大学学报Issue(2)：67-72,6.
开颅手术后小剂量芬太尼PCIA对患者血浆内皮素的影响
Effect of PCIA with Low-dose Fentanyl on Plasma Endothelin after Craniotomy
摘要
Abstract
Objective To investigate the effect of PCIA with low-dose fentanyl on plasma endothelin (ET) after craniotomy. Methods 47 cases of selected craniotomy were divided randomly into two groups :experimental group (26cases) and control group (21cases) . Patients in experimental group were treated with PCIA (fentanyl 15ug/kg +ondansetron 8 mg+100 mL NS) but patients in control group were not given PCIA. Then HR,MBP, VAS, ET and side-effects were observed and compared between two groups before treatment and 0, 2, 4, 8, 12, 24, 48 h after treatment.Results In experimental group, HR was lower at 2, 4, 8, 12, 24 and 48 h after treatment than control group. MBP was lower at 0 and 2h after treatment in experimental group than control group. Plasma levels of ET were lower at 8, 24 and 48h after treatment in experimental group than control group. There were significant differences in VAS scores at 2,4,8,12,24 and 48 h after treatment between two groups. There was no significant differences in side reactions including consciousness, respiratory depression, vomiting and sedation between two groups. The incidence of nausea was higher in experimental group than control group. Conclusion PCIA with low-dose fentanyl after craniotomy has good analgesic effect and few side reactions, can reduce the formation of plasma endothelin, and then alleviate brain damage.关键词
开颅手术/小剂量芬太尼/PCIA/血浆内皮素Key words
Craniotomy/Low-doses fentanyl/PCIA/Endothelin分类
医药卫生引用本文复制引用
杨文燕,邵文萍,王崇谦,乔飞..开颅手术后小剂量芬太尼PCIA对患者血浆内皮素的影响[J].昆明医科大学学报,2014,(2):67-72,6.基金项目
云南省科技厅应用基础研究基金资助项目 （）
