临床肝胆病杂志Issue(4)：367-369,3.DOI:10.3969/j.issn.1001-5256.2014.04.020
人工肝支持治疗下乙型肝炎相关慢加急性肝衰竭患者的近期预后分析
Analysis of short-term prognostic factors in patients with HBV-related acute-on-chronic liver failure treated with artificial liver support system
摘要
Abstract
Objective To investigate the short -term prognosis in hepatitis B virus (HBV)-related acute -on -chronic liver failure (ACLF)treated with artificial liver support system (ALSS)and its relationship with clinical indices including HBeAg and to provide refer-ence for the timely,accurate prognostic evaluation of HBV-related ACLF.Methods A retrospective analysis was performed on the clinical data of 81 patients with HBV-related ACLF (55 HBeAg-negative cases and 26 HBeAg-positive cases)who received ALSS treatment and comprehensive medical treatment.The HBeAg-negative cases and HBeAg-positive cases were compared in terms of treatment outcome and laboratory indices including alanine aminotransferase,total bilirubin,albumin,prealbumin (PA),cholinesterase,international normalized ratio (INR),blood ammonia,and alpha-fetoprotein (AFP).Comparison between two groups was made by chi-square test or non-para-metric test.Results There was no significant difference in treatment outcome between the HBeAg-negative cases and HBeAg-positive cases (P=0.158).There were significant differences in PA,AFP,and INR between the patients with response to treatment and those with-out response to treatment (P<0.000 1,P=0.000 5,and P<0.000 1).The receiver operating characteristic (ROC)curves of PA,AFP, and INR were drawn,and their areas under the ROC curves were 0.875,0.795,and 0.792,respectively.Conclusion There is no signifi-cant difference in treatment outcome between HBeAg-positive and HBeAg-negative patients with HBV-related ACLF treated with ALSS. PA,AFP,and INR can be used as accurate indices for prognostic evaluation of HBV-related ACLF.关键词
肝功能衰竭/肝炎,乙型/血浆置换Key words
liver failure/hepatitis B/plasma exchange分类
医药卫生引用本文复制引用
王贤,王少扬,黄德东,陈剑,陈德良..人工肝支持治疗下乙型肝炎相关慢加急性肝衰竭患者的近期预后分析[J].临床肝胆病杂志,2014,(4):367-369,3.基金项目
国家青年自然科学基金项目 （）
