中国临床保健杂志Issue(6)：630-633,0,5.DOI:10.3969/J.issn.1672-6790.2013.06.024
叶酸改善老年期轻度认知功能障碍大鼠学习记忆能力的机制
The mechanism of folic acid for improving the learning and memory abilities in elderly rats with mild cogni-tive impairment
摘要
Abstract
To investigate the mechanism of folic acid on the improvement of learning and memory abilities in the elderly rat model of mild cognitive impairment.Methods Forty elderly SD rats were randomly divided into four groups including a sham-operated contorl(SC)group,a model control(MC)group,a low dose(LD)group and a high dose(HD)group(n=10 in each group).30 days after operation,LD group(low-dose folic acid 4 mg·kg-1 ·d-1 ) and HD group(high-dose folic acid 12 mg·kg-1 ·d-1 )were given intragastric administration with folic acid tablets dissovled in saline daily for 30 days.The rats in SC group and MC group were given intragastric administration with the same dose of saline daily also for 30 days.On the 30th day of intragastric administration,we measured the learning and memory abilities,serum folic acid and plasma homocysteine concentration,GRK2 mRNA and protein expression in hippocampal tissues.Results The learning and memory abilities and serum folic acid concentration in HD and LD groups were all significantly higher than those of MC group(P<0.05).The plasma homocysteine concentration and GRK2 mRNA and protein expression in HD and LD groups were all significantly lower than those of MC group(P<0.05).Conclusion Supplementation of folic acid can improve the learning and memory abilities of elderly MCI rats. The mechanism may be related with increasing serum folic acid concentration,reducing plasma homocysteine concen-tration and decreasing GRK2 gene and protein expression in hippocampal tissues.关键词
认知障碍/叶酸/半胱氨酸/G蛋白偶联受体激酶2/大鼠,sprague-dawleyKey words
Cognitive disorders/Folic acid/Cysteine/G-Protein-Coupled receptor kinase 2/Rats,Sprague-dawley分类
医药卫生引用本文复制引用
柏慧,严光,胡世莲,孙梦雯,周树生,顾辨辨..叶酸改善老年期轻度认知功能障碍大鼠学习记忆能力的机制[J].中国临床保健杂志,2013,(6):630-633,0,5.基金项目
安徽省国际科技合作计划项目 （）
