岭南现代临床外科Issue(2)：153-156,4.DOI:10.3969/j.issn.1009-976X.2014.02.011
Tau蛋白表达与复发转移性乳腺癌紫杉醇化疗敏感性关系
The relationship of Tau protein expression with the sensitivity in taxane chemotherapy of recurrent and metastatic breast cancer
摘要
Abstract
Objective To investigate the expression of Tau protein in recurrent and metastatic breast cancer and the correlation between Tau protein and the effect of taxane-containing palliative chemotherapy. Methods The expression of Tao protein in the metastatic breast tumor tissue of 136 patients with recurrent and metastatic breast cancer was detected by immunohistochemistry.The correlation between the expression of Tao protein and clinical variables , such as taxane sensitivity and the associations between Tau expression and the efficiency of taxane-containing palliative chemotherapy was used by χ2 test or Fisher exact probability test. Results The expression of Tau protein in thirty-nine (28.68%, 39/136) patients was positive. The expression of Tau protein was positively related to ER (P<0.05) and negatively related with the effect of taxanes-containing palliative chemotherapy (P<0.01). Conclusion The expression of Tau protein was negatively related with the effect of taxane-containing palliative chemotherapy. The detection of the expression of Tau protein in recurrent and metastatic breast cancer may be a clinical basis to choose taxane-containing palliative chemotherapy.关键词
Tau 蛋白/复发转移/乳腺癌/紫杉醇Key words
Tau protein/Recurrent and metastatic/Breast cancer/Taxane分类
医药卫生引用本文复制引用
周婕,谭小军,何伟星,韩国栋,陈贵全,李洪胜..Tau蛋白表达与复发转移性乳腺癌紫杉醇化疗敏感性关系[J].岭南现代临床外科,2014,(2):153-156,4.基金项目
广州市医药卫生科技项目 （）
