泸州医学院学报Issue(5)：436-440,5.DOI:10.3969/j.issn.1000-2669.2013.05.005
祛风通窍方对血管性痴呆大鼠血液流变学及神经元细胞的影响
Eeffects of Qufeng Tongqiao decoction on hemorheology and neuron in vascular dementia(VD)rats
白雪 1钱海霞 1唐红梅 1张德绸 1王明杰1
作者信息
- 1. 泸州医学院附属中医医院心脑病科 四川泸州 646000
- 折叠
摘要
Abstract
Objective To observe the effect of Qufeng Tongqiao Decoction on hemorheology and hippocampal CA1 neuron changes of VD rats. Methods A total of 90 SD rats,12 rats were randomly assigned to sham group;after screen by Morris Water Maze test, the other 60 qualified rats were randomly divided into model group, nimodipine group (N group), high, medium and low dose Qufeng Tongqiao decoction groups (Q groups) 12 each. Permanent bilateral carotid artery ligation (2-VO) was used to VD model. The hemorheology changes were detected by quick rheometer, and the hippocampal neurons by electron microscopy. Results: Compared with sham group, blood rheology, neuronal changes, and apoptosis index (AI) in model group were significantly higher (P<0.05);compared with model group of the ultrastructure neuron of in N group and medium and high dose Q groups was significanly improved, while AI and blood rheology were significantly lower; the difference was statistically significant (P< 0.05). Conclusion: Qufeng Tongqiao decoction can improve the blood rheology, effectively reduce the neuron injury in VD rats, and inhibit neuronal apoptosis.关键词
祛风通窍方/血管性痴呆/神经元细胞/血液流变学Key words
Qufeng Tongqiao decoction/Vascular dementia/Neurons/Hemorheology分类
临床医学引用本文复制引用
白雪,钱海霞,唐红梅,张德绸,王明杰..祛风通窍方对血管性痴呆大鼠血液流变学及神经元细胞的影响[J].泸州医学院学报,2013,(5):436-440,5.
