国际眼科杂志Issue(12)：2411-2413,3.DOI:10.3980/j.issn.1672-5123.2013.12.13
HSV 载体用于中枢神经损伤基因治疗的研究进展
Research progress on herpes simplex virus vectors in gene therapy for central nervous system injury
摘要
Abstract
Gene therapy has increasingly shown a significant role in clinical trials in recent years, and has become a new treatment for the central nervous system diseases which conventional methods are difficult to cure. Herpes simplex virus ( HSV ) , a common human natural pathogen, has a natural neural tropism and can naturally infect post-mitotic neurons from retrograde infection of peripheral nerves into the central nervous system ( CNS) and has a long-term incubation.Therefore, HSV can be used as a means of delivery of exogenous genes.The optic nerve belongs to the CNS, thus, HSV vectors may be considered for gene therapy after optic nerve injury.In this paper, we reviewed the research progress of HSV as a vector for gene therapy after CNS injury and explained the feasibility of HSV for gene repair after optic nerve injury.关键词
单纯疱疹病毒/中枢神经系统/基因治疗/视神经损伤Key words
herpes simplex virus/central nervous system/gene therapy/optic nerve injury引用本文复制引用
庄静,马林昆,曹霞..HSV 载体用于中枢神经损伤基因治疗的研究进展[J].国际眼科杂志,2013,(12):2411-2413,3.基金项目
国家自然科学地区基金（ No．31160206）@@@@National Natural Science Area Foundation （）
