摘要
Abstract
AIM:To discuss the role of interleukin-6 ( IL-6 ) in the development of inflammatory glaucoma by detecting the IL-6 levels in serum and aqueous humor of inflammatory glaucoma patients. <br> METHODS: Totally 20 patients ( 20 eyes ) with inflammatory glaucoma were selected as experimental group, 20 patients ( 20 eyes ) with primary chronic glaucoma ( primary chronic angle-closure glaucoma and primary chronic open angle glaucoma ) as the high intraocular pressure control group, and 20 senile cataract patients ( 20 eyes ) as the normal control group.Three specimens of serum, aqueous humor in three groups were collected and aqueous IL-6 levels were measured through electrochemiluminescence. <br> RESULTS: The serum IL -6 levels in Inflammatory glaucoma group, primary chronic glaucoma group, senile cataract group were 3.26±2.10, 4.20±1.94 and 3.50 ±2.24pg/mL, respectively, which doesn't demonstrate statistically significant differences (F=1.080, P=0.345). The aqueous IL-6 levels in the Inflammatory glaucoma group, primary chronic glaucoma group and senile cataract group aqueous were 293.77±38.72, 135.27±32.72 and 115.80 ± 29. 97pg/mL, respectively, demonstrating statistically significant differences (F=164.86, P=0.000). The Inflammatory glaucoma group was found to be significantly higher than that in the primary chronic glaucoma and senile cataract group (P<0.01; P<0.01). Comparing the aqueous IL-6 levels in the primary chronic glaucoma group with that in the senile cataract group, the differences of it were not statistically significant (P>0.05). <br> CONCLUSION: High expression of IL -6 levels in aqueous humor of inflammatory glaucoma patients is closely associated with inflammation, but it has no significant correlation with high intraocular pressure.关键词
炎症性青光眼/免疫/白细胞介素-6Key words
inflammatory glaucoma/immunity/interleukin-6
