摘要
Abstract
AIM:To compare the difference and correlation of central corneal thickness ( CCT ) measured by Zeiss Visante Anterior Segment Optical Coherence Tomography ( Visante OCT ) , Heidelberg Slit -Lamp Anterior Segment Optical Coherence Tomography ( SL-OCT) , OrbscanⅡz Computerized Topography ( OrbscanⅡz ) and A-mode ultrasound pachymetry. <br> METHODS:Forty-three patients with myopia (86 eyes) were included. Sequential measurements of CCT was performed by the same operator with two different anterior segment OCT devices ( VisanteTM , Carl Zeiss, Meditec and Heidelberg EngineeringTM ), OrbscanⅡz Computerized Topography ( Bausch and Lomb IncTM ) and A-mode ultrasound pachymetry.The consistency of measurements was statistically analyzed by one-way ANOVA and LSD pair-wise comparisons.The differences were analyzed by Pearson correlation coefficients. <br> RESULTS:The average CCT measured by Visante OCT, SL -OCT, Orbscan Ⅱ z, and A -mode ultrasound pachymetry were (521.05 ±29.88)μm, (533.73 ±31.83)μm, (534.02 ±32.96 )μm, and ( 540.60 ±31.11 )μm, the 95%confidence interval were (514.57 ~527.54), (526.83 ~540.65), (533.85~547.35), (536.75~544.45).There was statistically significant difference of CCT between using of Visante OCT and SL-OCT ( P =0.009 ). There was statistically significant difference of CCT using of Visante OCT and A-mode ultrasound pachymetry ( P<0.01 ), OrbscanⅡ z ( P =0.008 ). The Visante OCT CCT measurements was significantly less than CCT with SL-OCT ( 12.69 ±9.32 ) μm. Compare with A -mode ultrasound pachymetry and OrbscanⅡz, the Visante OCT measurements significantly underestimated central corneal thickness by a mean of ( 19.55 ±8.64 )μm and (12.96±12.21)μm.There was no significant difference of CCT between using of SL-OCT and A-mode ultrasound pachymetry (P=0.158), OrbscanⅡz (P=0.954).There was no significant difference of CCT between using of OrbscanⅡz and A-mode ultrasound pachymetry ( P=0.176 ) . There were positive correlationship among Visante OCT, SL-OCT, OrbscanⅡz, and A-mode ultrasound pachymetry in CCT measurement ( P <0.01 ) . <br> CONCLUSION: There are excellent correlationship among Visante OCT, SL-OCT,OrbscanⅡz, and A-mode ultrasound pachymetry in CCT measurement.The data shows that the CCT obtained by SL-OCT and OrbscanⅡz do not have significant difference as compared with that from the A-mode ultrasound pachymetry.Three optical measurement devices is more likely to be accepted by patients because of its non-contact, non-invasive, and short measurement time as compared with the A-mode ultrasound pachymetry.关键词
眼前段光学相干断层扫描仪/裂隙灯型眼前段光学相干断层扫描仪/OrbscanⅡz角膜地形图/角膜测厚系统/A型超声测量仪/中央角膜厚度Key words
Visante OCT/SL-OCT/OrbscanⅡz/A-mode ultrasound pachymetry/central corneal thickness
