国际眼科杂志Issue(3)：416-418,3.DOI:10.3980/j.issn.1672-5123.2014.03.09
地塞米松对大鼠角膜酸烧伤疗效初探
Preliminary study of dexamethasone's curative effect of acid burns on rat cornea
摘要
Abstract
AIM:To research the curative effect of dexamethasone on rat cornea acid burn at different periods. <br> METHODS: The 40 corneal acid burned eyes of the 40 SD rats were divided into 4 groups with each group of 10 eyes randomly.Ⅰ, Ⅱ, Ⅲ groups were treated with dexamethasone (1mg/mL) eye drops at three periods after the corneal burns ( acute stage, 0-3d; early repair, 3-7d;late repair, 7-21d);theⅣgroup is treated without dexamethasone.The injured eyes were photographed and dynamically observed with slit lamp microscope, and the histological changes were scrutinized with HE staining. <br> RESULTS: Eventually, the cornea repairing situation from good to bad is:Ⅲ,Ⅰ,Ⅳ,Ⅱ.After acid burned, corneal epithelial healing and angiogenesis area were different, the comparison between the experimental groups and control group was statistically significant (P<0.01). <br> CONCLUSION: After acid burned, curative effects are different with using dexamethasone at different periods. Active effects were produced after using dexamethasone in the acute stage and the late stage.However, using dexamethasone in the early stage may hinder the repairing of cornea, or even dissolve the cornea.关键词
角膜/酸烧伤/地塞米松/疗效Key words
cornea/acid burn/dexamethasone/curative effect引用本文复制引用
何凯文,黄焱,王婷婷,张鹏,董芮甫,车荧霞,丁慧珍..地塞米松对大鼠角膜酸烧伤疗效初探[J].国际眼科杂志,2014,(3):416-418,3.基金项目
2012年国家级大学生创新创业训练计划项目（ No．201210392025）；福建省自然科学基金项目（No．2011J01190）@@@@2012 National Training Programs of Innovation and Entrepreneurship for Undergraduates （ No．201210392025）；Natural Science Foundation of Fujian Province ， China （）
