国际眼科杂志Issue(5)：790-796,7.DOI:10.3980/j.issn.1672-5123.2014.05.02
吸烟,血清抗氧化维生素水平和老年性黄斑变性之间的关系
Smoking,serum antioxidant vitamin levels and age-related macular degeneration
Sezen Akkaya Çakir 1Ozlem Sahin 1Haluk Kazokoglu 1Feyza Tekeli 1Goncagul Haklar 2Yelda Özkurt3
作者信息
- 1. 土耳其，伊斯坦布尔34742，法提赫苏丹穆罕默德培训和研究医院
- 2. 土耳其，伊斯坦布尔34747，马尔马拉大学医学院眼科
- 3. 土耳其，伊斯坦布尔34747，马尔马拉大学医学院生物化学系
- 折叠
摘要
Abstract
AIM: To evaluate associations between the grades of age related macular degeneration ( AMD ) and serum levels of antioxidant vitamins ( vitamin A, C and E) and smoking. <br> METHODS:Fifty-three AMD patients and 31 individuals having ages matching with the patient group were enrolled the study. Colored fundus photographs of the macula were used to place participants ( n=84 ) into one of the five groups ( Grade I-V ) based on the frequency and severity of the lesions associated with AMD. Serum antioxidant vitamin levels were measured using High Performance Liquid Chromatography ( HPLC ) . Smoking status was classified as non-smoker, ex-smoker and current smoker. Total number of packs smoked per year, was defined. <br> RESULTS:The distribution of vitamin A, E, and C levels were 0. 874±0. 326mg/L, 10. 739±4. 874mg/L, 1. 737±0.447mg/L in control group and 0. 880±0. 305mg/L, 9. 487±6. 060mg/L, 1. 870±2. 191mg/L in AMD group, respectively. The difference between AMD and control group was not statistically significant for vitamin A, E and C levels ( P>0.05 ) . There were no significant differences between subgroups of AMD for vitamin A (P=0. 881) and vitamin E (P=0. 293) but there was a contradicting rise of vitamin C levels ( P=0. 044 ) with increasing levels of the disease. There were no significant differences between AMD and control group regarding smoking status, but there was a significant difference for total number of packs smoked per year (P=0. 02). An increase of number of total packs smoked per year was determined along with the rising grade of AMD (P=0. 007). <br> CONCLUSION:We found no relation between AMD and serum levels of vitamin A and E but vitamin C levels was increase with AMD grades unexpectedly. We found dose-response relationship between smoking and AMD.关键词
吸烟/抗氧化维生素/老年性黄斑变性Key words
smoking/antioxidant vitamin/age related macular degeneration引用本文复制引用
Sezen Akkaya Çakir,Ozlem Sahin,Haluk Kazokoglu,Feyza Tekeli,Goncagul Haklar,Yelda Özkurt..吸烟,血清抗氧化维生素水平和老年性黄斑变性之间的关系[J].国际眼科杂志,2014,(5):790-796,7.
