摘要
Abstract
Objective To explore the effect of a single low-dose of cyclophosphamide pulse therapy ( CPT) by intermit-tent infusion on adult refractory nephrotic syndrome ( RNS) and identify any features of cyclophosphamide ( CTX) toxicity. Meth-ods The study group consisted of 22 adult RNS hospitalized patients. They were treated 3 ~4 times per month at a single low-dose of CPT (0. 2g /qod) by intravenous infusion for 3 months (CTX 1. 8 ~2. 4g), then repeated it every 2 months for 6 months, total 9 months (CTX 3. 6~4. 8g). At the same time these patients were treated with prednisone 8 ~12weeks 0. 5mg/( kg ·d) , anticoagulant and antiplatelet therapy. Any adverse reactions of CTX were observed in these patients by examination. Results Complete remission (CR) was observed in 5 (22. 7%) and partial remission (PR) in 16 (72. 7%) patients after 3 months,one patient was invalid (4. 5% ). After 9 months of treatment CR was observed in 19 (86. 4%) and PR in 2 (9. 1%) patients, one patient was invalid (4. 5%), in remission patients (CR+PR) the level of serum albumin increased markedly (P<0. 01), proteinuria and cholesterol (CHO) were reduced significantly (P<0. 01; P<0. 05,respectively). The reduced renal function in 4 patients before treatment returned to normal. side-effects were minimal. Conclusion A single low-dose of CPT by intermittent infusion enhanced significant remission rate of adult RNS with minimal side-effects.关键词
环磷酰胺/难治性肾病综合征Key words
cyclophosphamide/refractory nephrotic syndrome分类
医药卫生
