摘要
Abstract
Objective:To explore the clinical significance and expression of matrix metalloproteinase -2,9(MMP-2,9) and tissue in-hibitor of metalloproteinase -1,2(TIMP-1,2) in serum and peritoneal fluid of patients with endometriosis (EMs).Methods:We meas-ured the concentrations of MMP -2,9 and TIMP-1,2 in serum and peritoneal fluid of patients with EMs (n=37) and compared them with those in a control group(n=25),as assessed by enzyme -linked immunosorbent assay (ELISA).Results:MMP-2,9 concentrations in serum and peritoneal fluid were higher in patients with EMs than those in the control group (p<0.05), while TIMP-1,2 concentra-tions in serum and peritoneal fluid were lower in patients with EMs than those in the control group (p<0.05).MMP-2,9 concentrations in serum and peritoneal fluid of stage ⅢorⅣwas higher than that of stageⅠorⅡ(p<0.05), TIMP-1,2 concentrations in serum and peritoneal fluid of stage Ⅲor Ⅳwas lower than that of stageⅠorⅡ(p<0.05).Conclusion:These results suggest that MMP -2,9 and TIMP-1,2 may play an important role in the pathogenesis of EMs .Detection of MMP-2,9 and TIMP-1,2 in serum and peritoneal fluid has important clinical value to diagnostic , treatment and prognosis of patients with EMs .关键词
子宫内膜异位症/基质金属蛋白酶/基质金属蛋白酶组织抑制因子Key words
Endometriosis/Matrix metalloproteinase/Tissue inhibitor of metalloproteinase/Serum分类
医药卫生
