神经病学与神经康复学杂志Issue(3)：143-146,150,5.
皮质下型血管性认知障碍的核磁共振视觉半定量分析
The MRI semi-volumetric analysis of subcortical vascular cognitive impairment
摘要
Abstract
Objective To explore the neuroimaging markers of subcortical vascular cognitive impairment ( s-VCI) . Methods Based on the detailed neuropsychological tests and clinical interview , 92 subjects with subcortical ischemic vascular disease ( SIVD ) were recruited and classified into three groups according to their cognitive state, 29 patients with no cognitive impairment (NCI), 39 patients with vascular mild cognitive impairment ( VaMCI ) , and 24 patients with vascular dementia ( VaD ) . Their demographic , vascular risk factors and neuroimaging data were compared . Results The differences between the three groups in the number of subcortical white matter lacunar infarcts ( LI) as well as the scores of the white matter lesions ( WML) , medial temporal atrophy (MTA) and cerebral atrophy (CA) were statistically significant .Pairwised analysis showed that the numbers of LI within subcortical white matter in the VaMCI ( P<0.01 ) or VaD group ( P<0.05 ) were significantly higher than that in the NCI group .The scores of WML in the VaD group were significantly higher than that in the VaMCI or NCI group ( all P<0.01 ) .The scores of MTA in the VaD group were also significantly higher than that in the NCI group ( P<0.01 ) .The scores of CA in both groups of VaMCI and VaD were significantly higher than that in the NCI group (all P<0.05).The scores of WML, MTA, and CA, as well as the numbers of LI within subcortical white matter ( all P<0.05 ) and total LI numbers ( P<0.05 ) in patients with VCI were significantly higher than that in patients with NCI .Logistic regression analysis showed that low level of education , diabetes mellitus , the numbers of LI within subcortical white matter , the scores of MTA and CA were independent risk factors for s-VCI . Conclusion s-VCI is independently related to low level of education , diabetes mellitus , subcortical white matter injuries , as well as cortical and medial temporal atrophy .关键词
血管性认知障碍/皮质下缺血性血管病/核磁共振/危险因素Key words
vascular cognitive impairment/subcortical ischemic vascular disease/MRI/risk factors分类
医药卫生引用本文复制引用
徐群,曹雯炜,周滟,李焰生..皮质下型血管性认知障碍的核磁共振视觉半定量分析[J].神经病学与神经康复学杂志,2013,(3):143-146,150,5.基金项目
上海市卫生局科研课题（编号20124251）和上海交通大学医工（理）交叉基金 （）
