世界中医药Issue(9)：1101-1104,4.DOI:10.3969/j.issn.1673-7202.2013.09.035
基于复杂网络的心绞痛血瘀证中药组方研究
Study on Formulating Rules of Chinese Herbal Formula for Treating Angina Blood Stasis Syndrome
摘要
Abstract
Based on clinical data of TCM formula for treating angina blood stasis syndrome , a Chinese herbal network for treatment of angina blood stasis syndrome was built up by using scale-free network, degree centrality, betweenness centrality and closeness centrality of Chinese herbs were calculated , and subgroup analysis was performed by using CONCOR method .It was found that salvia miltiorrhiza , rhizoma ligustici wallichii , astragalus root , safflower and radix Notoginseng exhibit high centrality , indicating they were crucial compo-nent of the formula to treat of angina blood stasis syndrome .Twenty seven subgroups were discovered , four subgroups are valuable for new TCM formula design .In order to analyze potential compatibility of Chinese herbs , CONCOR analysis was performed on subgroups to obtain network density , and provided explanations from Chinese medicine theory .Conclusion:Scale-free network calculation is a useful method to design TCM formula for treating angina blood stasis syndrome .关键词
复杂网络/心绞痛血瘀证/中心度/凝聚子图/ucinet软件Key words
Scale-free Network/Angina blood stasis syndrome/Centrality/Subgroup analysis/Ucinet引用本文复制引用
雷蕾,杨策,温先荣,邢雁辉,刘骏,王忠..基于复杂网络的心绞痛血瘀证中药组方研究[J].世界中医药,2013,(9):1101-1104,4.基金项目
863计划课题（编号2006AA01A122）中国中医药科学数据网格服务应用，负责人崔蒙；中国中医科学院基本科研业务费自主选题项目（编号ZZ050305），基于支持向量机的中药组分药理作用预测模型的研究，负责人雷蕾；“重大新药创制”科技重大专项“大品种药物 IV期临床试验及新药临床试验审评研究技术平台”子课题-“丹红注射液IV期临床试验研究”（编号2011ZX09304-07），负责人南景一 （）
