世界中医药Issue(10)：1147-1149,3.DOI:10.3969/j.issn.1673-7202.2013.10.005
人参皂苷Re对大鼠心室肌细胞钠、钾离子通道的影响
Effects of Ginsenoside Re on Sodium and Potassium Current in Rat Ventricular Myocytes
摘要
Abstract
Objective:To investigate the effects of Ginsenoside Re on voltage-dependent sodium current and potassium current in rat ven-tricular myocytes , and to investigate the mechanism of antiarrhythmia .Methods:The effect of Ginsenoside Re on sodium current ( INa ) , transient outward potassium current ( Ito) and inwardly rectifie-d potassium current ( Ik1 ) were assessed by applying whole-cell patch clamp technique in single cardiac myocytes .Results:Ginsenoside Re (10 ,100μmol· L-1)) was shown to inhibit the altitude of INa and the inhibition ratio was 25.5 ±5.7%(n=3)and 46.2 ±18%(n=4).It was shown a little inhibition by Ginsenoside Re (100μmol · L-1)) and its effects were reversible completely after washout .The inhibition ratio of Ito was 13 ±9%(n=3)in 100μmol· L-1). Ginsenoside Re (10 ,100μmol· L-1)) inhibited the altitude of Ik1 and the inhibition ratio was 16.3 ±8.7%(n=5)and 35.4 ±11.2%(n=5).Conclusion:Ginsenoside Re can inhibit sodium current and potassium currents to produce antiarrhythmic effect .关键词
人参皂苷Re/膜片钳/钠通道电流/钾通道电流Key words
Ginsenoside Re/Pathch clamp technique/Sodium current/Potassium current引用本文复制引用
孟红旭,姚明江,刘建勋..人参皂苷Re对大鼠心室肌细胞钠、钾离子通道的影响[J].世界中医药,2013,(10):1147-1149,3.基金项目
中国中医科学院自助选题项目（编号zz070821），科技部十二五重大新药创制课题 （）
