世界中医药Issue(12)：1393-1396,4.DOI:10.3969/j.issn.1673-7202.2013.12.004
缺血性心力衰竭气虚血瘀证和阳虚水停证的代谢组学研究
Metabolomics-Based Study on Ischemia Heart Failure With Syndrome Of Blood Stasis Caused By Qi Deficiency And Syndrome Of Fluid Accumulation Caused By Yang Deficiency
摘要
Abstract
Objective:To investigate metabolomics characteristics of serum samples in ischemia heart failure with syndrome of blood sta -sis caused by qi deficiency ( QDBS) and syndrome of fluid accumulation caused by Yang Deficiency ( YDFA) and explore the applica-tion of metabolomics in study of TCM syndrome of ischemia heart failure .Methods:The serum samples of ischemia heart failure with QDBS (n=18) and YDFA (n=18) were detected by Liquid chromatography-mass spectrometry(LC-MS) and analyzed based on Prin-cipal Component Analysis ( PCA) and Partial Least Squares Discriminant Analysis ( PLS-DA) .Results:Ischemia heart failure with QDBS and YDFA can be distinguished clearly by PLS-DA.There was significant difference in metabolic characteristic between the two groups . Compared with QDBS ,3 metabolites belonged to Lysophosphatidylcholines decreased in YDFA;3 metabolites belonged to carnitines and 2 metabolites belonged to fatty and creatinine increased in YDFA .Conclusion:Energy metabolism and phospholipid metabolism were different between ischemia heart failure with QDBS and YDFA .Metabolomics analysis based on LC/MS can distinguish the two groups and provide new detective method for TCM syndromes differentiation objective .关键词
缺血性心力衰竭/气虚血瘀证/阳虚水停证/代谢组学Key words
Ischemia heart failure/Syndrome of blood stasis caused by qi deficiency/Syndrome of fluid accumulation caused by Yang Deficiency/Metabolomics引用本文复制引用
王鹏军,孙明谦,苗阳,刘玲玲..缺血性心力衰竭气虚血瘀证和阳虚水停证的代谢组学研究[J].世界中医药,2013,(12):1393-1396,4.基金项目
国家自然科学基金资助项目 （）
