世界中医药Issue(12)：1461-1464,4.DOI:10.3969/j.issn.1673-7202.2013.12.026
增液汤干预干燥综合征模型鼠 AQP1／AQP8的表达规律研究
Intervention of Zengye Decoction on Expression of Aquaporin-1,8 in the Mice with Sjogren’ s Syndrome
摘要
Abstract
Objective:To observe the expressions of AQP1 and AQP8 in lung and colon tissue of mice with Sjogren's syndrome.Meth-ods:Fifty BALB/c mice were randomized into five groups ,with10 mice in each group .The mice models with Sjogren's syndrome were es-tablished by immune inducing method .It was able to produce the specific clinical symptoms and pathological changes of Sjogren 's syn-drome.The effect of Zengye decoction on the expression of AQP 1/AQP8 in lung and colon tissue was observed by immunohistochemistry and Western blot.Results:Zengye decoction can strengthen the AQP1 protein expression in lung and colon tissue (P<0.01),however AQP8 was barely changed .Conclusion:It could be one of the causes of Sjogren's syndrome that AQP1 expression was reduced in multi-ple organ in the mice with Sjogren’s syndrome.Zengye decoction can increase the body fluid ,and the effect may be associated with the increased AQP1 expression .关键词
AQP1/AQP8/干燥综合征/Western blot/增液汤Key words
AQP1/AQP8/Sjogren's syndrome/Western blot/Zengye decoction引用本文复制引用
吴晓丹,任长虹,张林,周洪伟,程涓,杨勇..增液汤干预干燥综合征模型鼠 AQP1／AQP8的表达规律研究[J].世界中医药,2013,(12):1461-1464,4.基金项目
国家自然科学基金青年科学基金资助项目 （）
