世界中医药Issue(12)：1467-1470,4.DOI:10.3969/j.issn.1673-7202.2013.12.028
姜露散对大鼠感染性创面提脓祛腐的作用及机制
Effect and Mechanism of Jianglu Powder in Absorbing Pus and Removing Slough on Infected Wound Surface of Rats
摘要
Abstract
Objective:To explore the effect and mechanism of Jianglu powder ( JLP) in absorbing pus and removing slough on infected wound surface of rats .Methods:Rat models of infected wound surface on the back were successfully established .The model rats were randomly divided into the JLP group ,the Jiuyi Powder ( JYP) group and the model group .The wound surfaces of rats in JLP group were treated with JLP ,while those in JYP group were given JYP every day .The wound surfaces of rats in model group were only treated with normal saline (NS) every day.The treatment lasted for fourteen days.The rats’ general situation and the dropping off time of pus and slough were observed.On the 3rd,7th,and 14th day,the amount of wound surface secretion was calculated .The level of macrophages lyso-some in wound tissues was detected by immunohistochemistry;the content of IL-1βin wound tissues was detected by ELISA .On the 7 th and14th day,serum liver and renal function indexes were detected by enzymic method .Results:In terms of the dropping off time of pus and slough,JLP group and JYP group had significantly shorter results compared with the model group (P<0.01).As for score of wound surface secretion,on the 3rd day,JLP group and JYP group showed significantly higher outcomes than model group (P<0.01).In terms of the level of macrophages lysosome in wound tissues ,on the 3rd and 7th day,JLP group and JYP group had significantly higher scores than the model group(P<0.01).The content of IL-1βin wound tissues on the 3rd and 7th day in JLP group and JYP group were significantly more than those in model group (P<0.01).Serum total BUN,CREA and ALT:on the 7th and 14th day in JYP group was significantly higher than JLP group and model group (P<0.05).Conclusion:JLP could absorb pus and remove slough of infected wound surface by increasing the level of macrophages lysosome and IL-1βin wound tissues .The safety of JLP is better than Shengdan preparation ( JYP) .关键词
姜露散/感染性创面/提脓祛腐/创面修复/溶菌酶/IL-1β/升丹制剂Key words
Jianglu powder/Infected wound surface/Absorbing pus and removing slough/Wound healing/Macrophages lysosome/IL-1β/Shengdan preparation引用本文复制引用
王佳雯,陆金根,曹永清,潘一滨..姜露散对大鼠感染性创面提脓祛腐的作用及机制[J].世界中医药,2013,(12):1467-1470,4.基金项目
上海高校青年教师培养资助计划（编号shzy023）；国家中医药管理局重点学科-肛肠学科资助；海派中医流派传承研究基地-顾氏外科（编号ZYSNXD-CC-APGC-JD002）；上海市科委科研计划项目 （）
