世界中医药Issue(12)：1474-1477,4.DOI:10.3969/j.issn.1673-7202.2013.12.030
益肾化浊颗粒对腺嘌呤饲喂法所致慢性肾衰大鼠血清中 Bun，Crea 含量的影响
Effects of Yishenhuazhuo granules on Bun and Crea in Serum of Adenine Feeding Method Induced Chronic Renal Failure Rats
刘学文 1杨卫彬 2荆志伟2
作者信息
- 1. 首都医科大学潞河教学医院中医科，北京，101100
- 2. 中国中医科学院，北京，100700
- 折叠
摘要
Abstract
Objective:To investigate the effect and mechanism of Yishenhuazhuo granules on Adenine feeding method induced chronic renal failure Rats.Methods:The rats were fed with 0.75%adenine to make the models of chronic renal failure , then they were ran-domly divided into six groups , including blank control group , model control group , Niaoduqing granules control group and Yishenhua-zhuo granules with large , medium and small dosage groups .After administered continuously for 30 days, kidney index were calculated , Bun and Crea content in serum were determined by using ELISA method , and renal pathological changes were observed by using HE stai-ning.Results:Compared with model control group of drug-treated rats, kidney index differences were not statistically significant , serum Bun and Crea were significantly reduced in each administration group , and tubular dilatation in Yishenhuazhuo granules large dosage group was slight (P<0.05).Conclusion: Yishenhuazhuo granules could reduce Bun and Crea content in serum in Adenine feeding method induced chronic renal failure rats , and improve renal pathological changes .关键词
益肾化浊颗粒/慢性肾功能衰竭/尿素氮/肌酐Key words
Yishenhuazhuo granules/Chronic renal failure/Blood urea nitrogen/Creatinine引用本文复制引用
刘学文,杨卫彬,荆志伟..益肾化浊颗粒对腺嘌呤饲喂法所致慢性肾衰大鼠血清中 Bun，Crea 含量的影响[J].世界中医药,2013,(12):1474-1477,4.
