世界中医药Issue(4)：468-469,474,3.DOI:10.3969/j.issn.1673-7202.2014.04.023
蜈蚣三七纳米粉预防大鼠术后肠粘连的机制研究
Study on Mechanism of Nano-powder of Wugongsanqi in Preventing Postoperative Intestinal Adhesion in Rats
摘要
Abstract
Objective:To investigate the anti-inflammatory mechanism of nano-powder of Wugongsanqi ( NW) , the rhizome of Anemone flaccid, on postoperative intestinal adhesion in rats .Methods:Fifty SD rats were subjected to operation with Ellis'method for establis-hing intestinal adhesion models , then randomly divided into 5 groups (n=10), namely model, positive (Dexamethasone, i.m.10 mg/kg), NW high, medium and low dose group (p.o.450, 225 and 112 mg/kg, respectively).Another ten normal rats were selected as control group .Drugs were given 3 days before the operation until 7 days after the operation .The intestinal adhesion was graded and the levels of TNF-α, IL-1βand IL-6 in serum were evaluated by ELISA .Results:NW evidently reduced the severity of postoperative adhe-sion (P<0.05 or P<0.01), and significantly inhibited the levels of TNF-α, IL-1βand IL-6 in serum (P<0.05 or P<0.01), com-pared with those of the model group .Conclusion:NW could effectively prevent the formation of postoperative intestinal adhesion by in -hibiting the expression of inflammatory cytokines and improving the inflammatory response .关键词
蜈蚣三七/肠粘连/TNF-α/IL-1β/IL-6Key words
Anemone flaccida/Intestinal adhesion/TNF-α/IL-1β/IL-6分类
医药卫生引用本文复制引用
黄欣,李一鸣,徐福琴,何明钎,邴飞虹..蜈蚣三七纳米粉预防大鼠术后肠粘连的机制研究[J].世界中医药,2014,(4):468-469,474,3.基金项目
湖北省教育厅科研计划重点项目（编号D20101802）；深圳市科技局项目 （）
