色谱Issue(4)：395-401,7.DOI:10.3724/SP.J.1123.2013.11001
电喷雾离子源中样品离子化能量转移理论的初探
Preliminary exploration of energy transfer about sample ionization process in electrospray ionization source
摘要
Abstract
Electrospray ionization source(ESI)can be used not only for the detection of small molecules,but also for large molecules such as proteins and peptides. This article proposes energy transfer theory based on the lowest energy principle by systematically analyzing ioniza-tion processes. The transference of the analyte from liquid phase to gas phase can be influenced by multiple forces during the ionization and vaporization processes,such as electrostatics force and van der Waals’force. The ionization of samples is the result of the interactions among mul-tiple forces. During different stages of the ionization process,different forces lead to different effects. There are competition between evaporation and formation of multi-charge ions for char-ges. For molecules with different structures,Gibbs free energy between two phases from the changes of molecule shape or conformation may lead to ion evaporation,multiply charged mac-romolecule and chain ejection,etc. The energy transfer theory can simplify the three existing theories,as well as explain the solvent effect and electrolyte ion effect during ionization process. The proposed theory provides foundation to optimize the detection condition for differ-ent samples and to understand the real process of ionization.关键词
电喷雾离子源/电荷转移能/能量最低原理/样品离子化Key words
electrospray ionization source(ESI)/charges transfer energy/principle of lowest energy/sample ionization分类
化学化工引用本文复制引用
张维冰,高方园,关亚风,张玉奎..电喷雾离子源中样品离子化能量转移理论的初探[J].色谱,2014,(4):395-401,7.基金项目
国家自然科学基金项目（21235005）；国家重大仪器设备开发专项项目（2012YQ120044）． （）
