陕西医学杂志Issue(10)：1290-1292,3.
8-甲氧基补骨脂素柔性纳米脂质体不同研制方法的比较
The comparison of different method for flexible nano-liposome of 8-methoxypsoralen
摘要
Abstract
Objective:Screening suitable method for preparing flexible nano-liposome of 8- methoxypsor-alen .Methods :According to orthogonal experimental design and pre-test the basic recipe was determined :soybean lecithin :cholesterol:MOP:sodium cholate = 20 :10:3 :10 .MOP flexible nano-liposomes were prepared by using ei-ther reverse-phase evaporation method ,aether infusion method ,film-dispersion or film-dispersion-ultrasound meth-od .Liposomal envelopment efficiency ,the average particle size and zeta potential were compared between different methods .Results :Reverse-phase evaporation method has low envelopment efficiency and large particle size ;aether infusion method has low envelopment efficiency and small particle size ;film-dispersion method has high envelopment efficiency and large particle size ;film-dispersion-ultrasound method has high envelopment efficiency and suitable par-ticle size and zeta potential .Conclusion:The film-ultrasonic method with ultrasonic time of 15 minutes for preparing MOP flexible nano liposome is a more appropriate method .关键词
脂质体/纳米结构/@8-甲氧基补骨脂素Key words
Liposomes/Nanostructures/@8-methoxy psoralen分类
医药卫生引用本文复制引用
郑荣昌,马静,周贵滨,秦思,温炬..8-甲氧基补骨脂素柔性纳米脂质体不同研制方法的比较[J].陕西医学杂志,2013,(10):1290-1292,3.基金项目
广东省科技计划项目 （）
