陕西医学杂志Issue(12)：1574-1575,1580,3.
PPARγ激动剂吡格列酮对大鼠脑缺血再灌注损伤的作用研究
Effects of peroxisome proliferator activated receptor γ Pioglitazone on cerebral ischemic injury in rats
摘要
Abstract
Objective :To investigate the role of peroxisome proliferator activated receptor γ (PPARγ)in cerebral ischemic injury by PPARγagonist pioglitazone treating in rats .Methods :One seventy-two Sprague-Dawley (SD) rats were randomly divided into sham group ,middle cerebral artery occlusion (MCAO) group and pioglitazone treatment group .At 24h after ischemia-reperfusion injury ,neurological impairment was evaluated by neurological deficit score (NDS) ,infarct volume was measured by dUTP nick-end labeling 2 ,3 ,5 ,-triphenyltetrazolium chlo-ride (TTC) staining , brain water content was measured by dry and wet weights of brain ,and neuronal apoptosis in the ischemic brain tissue was assessed in situ by terminal deoxynucleotide transferase-mediated (TUNEL) staining at 24h after ischemic brain injury .Results :Compared with MCAO group rats ,NDS(P<0 .05) ,infarct volume(P<0 . 05) ,brain water content(P<0 .01) and neuronal apoptosis(P<0 .01) in the ischemic brain tissue were significantly lower than those in GW501516 pretreatment group rats at 24h after ischemic brain injury ,respectively .Conclusion :pioglitazone ,a PPARγagonist ,has a neuroprotective effect on ischemic brain injury in rats ,and the antiapoptosis effect of pioglitazone may contribute to a beneficial effect against ischemic brain injury .关键词
缺血/并发症/再灌注损伤/过氧化物酶体增生物激活受体γ/动物 ,实验/大鼠Key words
Ischemia/complications Reperfusion PPARr Animals/laboratory Rats分类
医药卫生引用本文复制引用
狄政莉,张格娟,雍芳,田晔,常明则,王新来,顾乃兵..PPARγ激动剂吡格列酮对大鼠脑缺血再灌注损伤的作用研究[J].陕西医学杂志,2013,(12):1574-1575,1580,3.基金项目
陕西省自然科学基金 （）
