陕西医学杂志Issue(12)：1576-1578,3.
缬沙坦对大鼠急性心肌梗死后血清脑钠肽、内皮素-1和左室重构的影响
Valsartan on acute myocardial infarction serum brain natriuretic peptide endothelin-1 and left ventricular remodeling
摘要
Abstract
Objective :To observe the effects of the valsartan on serum brain natriuretic peptide (BNP) , serum endothelin-1(ET-1) and heart remodeling after acute myocardial infarction of rats .Methods :90 male wister rats were randomly divided into three groups :① sham group(n= 30);② AMI group(n= 30);③ AMI+ valsartan group(n=30) .Rats in the AMI+valsartan group were given the valsartan .Rat′s serum concentrations of BNP and ET-1 were tested at 30th day after operation while heart remodeling (LAD、LVESD、LVEDD) were measured .Re-sults :Compared with AMI Group ,the blood serum levels of BNP and ET-1 in AMI+valsartan Group rats was smal-ler(P<0 .05) ,and similarly LAD、LVESD、LVEDD in AMI+valsartan Group rats were smaller too .Conclusions :This showed that the valsartan can lessen the increase of BNP and ET-1 blood serum levels and delay the remodeling progress of AMI at 30th day after operation .关键词
心肌梗塞/缬沙坦/利钠肽 ,脑/内皮缩血管肽-1Key words
Myocardial infarction Valsartan Natriuretic peptide/brain Endothelin-1分类
医药卫生引用本文复制引用
杜文涛,刘秀平,张辉,白净,袁江永,刘贵京,史素芳..缬沙坦对大鼠急性心肌梗死后血清脑钠肽、内皮素-1和左室重构的影响[J].陕西医学杂志,2013,(12):1576-1578,3.基金项目
河北省邯郸市科学技术研究与发展计划 （）
